Epson Software Film Factory v2.5 Manual de usuario

Advanced Specialty Ingredients 1361 Alps Road Wayne, NJ 07470 UUSSEERR MMAANNUUAALL FilmQA™ Pro Version: 3.0.4864.35322 Date: J

8 defined areas of interest and the size and position of a user-defined profile path across an image. Keep in mind that navigating through F

98 The next step is the MLC Design. For this example, the Varian Millennium 80 MLC is used. Select the MLC Design using the icon.

99 Adjustments are complete when the leaf borders on the film line up with the overlaid MLC leaf borders (solid blue lines, dotted blue line

100 To account for such deviation, FilmQA™ Pro offers the following profile normalization options:  Normalize global minimum and maximum

101  Truncate at smallest local minimum and maximum values and normalize to 0 and 1: Truncate lower part of the profile at highest minimum

102 When the analysis is complete, select the “Report” tab to summarize the results of the case. Enable items that should be included in the

103 EDITORS The Bitmap Color Translation Editor is the first editor and allows the user to create, edit and delete color translations to the

104 The “color translation list” shows a list of color translations that are available at the working panel. The user can view, select and de

105 Figure 1 2. Enter the name and description of the color map. If necessary, the color icon can be changed (see below).

106 3. Color translations can be mapped to any image. When such translations are needed, one can access them via the “Color Translation Tool

107  The “Displayed Color Selector” icon, allows you to select the displayed colors and effects in the test image of the “Preview

9  “Configuration” – Loads/saves FilmQA™ Pro configuration settings from a new drop-down list  “Auto Save” – Saves the configuration au

108 CONFIGURATION FilmQA™ Pro has an extensive library of functional subroutines to execute an array of tasks in radiochromic film dosimetry

109 To add a treatment object to the active list, click on the object to highlight it. Then click the icon between the two lists to transf

110 TROUBLESHOOTING Installation Issues: 1. Make sure security programs or virus scanners are disabled prior to installing. 2. If program d

111 Film Issues: 1. When using the EPSON V700 Photo scanner, remove film after scanning is complete. Unlike the EPSON 10000XL, the lamp stay

112 7. During a “Film Calibration – Mosaic” if many large strips are being used, the images may need to be cropped. Too many strips could re

113 Appendix A Calibration Protocol for Radiochromic Film I. PURPOSE To define an efficient protocol for calibration of radiochromic dos

114 Figure 1 Contrast this to the behavior when the same data is fitted to polynomial functions (in this case 4th order) as shown in Figure

115 The benefit of using the type of rational function described above is that you can actually reduce the number of dose points required for

116 V. PROCEDURE The film sizes could be 1.5” x 8” strips, or 8” x 10” sheets or anything between. If multiple films are used they must have

117 2. Expose the calibration film to a known dose about 30% greater than the highest dose expected for an application film. One way is to u

10  “Object Type Management” displays the Case Object library allows various objects to be activated and therefore available from the drop

118 Figure 1 6. Expand the Film Calibration case object, right click on “Data Calibration Film (empty)” and select and click “Scan Image C

119 Figure 3A Figure 3B Figure 3C 7. Place the calibration films and an unexposed film from the same lot o

120 8. Use the Frame Tool to mark areas of interest in the centers of the calibration strips (Figure 5). Figure 5 9. Click the “

121 applicable to other films from the same production lot scanned on the same scanner. Figure 7

122 APPENDIX B An Efficient Protocol for Radiochromic Film Dosimetry I. PURPOSE To define a radiochromic film dosimetry protocol to meas

123  Epson ® Scanner Software  FilmQA™ Pro Software IV. PROCEDURE Films used in this protocol are of two sorts, strips and sheets. Str

124 3. Expose the phantom/film to the chosen radiotherapy treatment plan and note the time. Remove the application film from the phantom. Ke

125 Figure 1 7. Add a new case object choosing “Add Dose Map Single Scan” (Figure 2) Figure 2

126 8. Expand the Dose Map selection. Right click “Data - dose film” choosing “Scan Image ‘dose film’” from the drop down menu. The Epson® D

127 Figure 4 10. Use the Frame Tool to select areas of interest in the centers of the calibration strips. Figure 5 Start of scan Scan D

11 Data, as the name describes, includes all data related to the patient, treatment case or scanner. This tab also allows the changing of me

128 11. Right click the areas of interest (Figure 6A) to name the region types as “Calibration Region”. Then right click the regions, select

129 Figure 7A Figure 7B 13. Compare the measurements with the plan. Add a New Case Object – “Dose to Plan Comparison” (Figu

130 Figure 9 Tabs on the left edge of the right frame (Figure 9) change the display type in the right window: Statistics, Profile, Isolines

131 APPENDIX C Post-Exposure Change Exposure of radiochromic film to ionizing radiation starts a solid-state polymerization in crystals o

132 From the data in Figure B-1, it is calculated that at time-after-exposure of 30 minutes, a 5-minute timing difference could contribute to

133 Index A B Beam Line Detection 97 Bitmap Color Translation Editor 103 C Calibration 28 Case Data Selector

12 predetermined color mixes. Colors can always be returned to default settings by selecting “Reset to Default Colors”  “Label Position” ch

13  “Reset History” – Clear all events  “Word Wrap” – Wrap the words to fit the window width  “Filter” (see arrow above) allows you to

14 Help is the last category and provides instructional information such as the user’s manual, license data generator, license expiration not

15  “Case Data” opens a drop down list to select case specific information related to the patient. Double-click the icon to open the pop-up

16 By default the first Dose Map in the case is used. In the Dose-to-plan Comparison branch of the Case Tree select a different dependency if

17 Case Data Selector shows the case management tree which allows you to add selected image objects into case data. It is located on the left

Table of Contents Introduction 1 Installation 2 Getting Started 7 Operatio

18 for some scanner drivers which would auto rotate the image without rotating the device information (e.g. Epson used in conjunction with Wi

19 IMAGE PANEL Image Panel displays the image and user-defined regions of interest for dose calibration and measurement. It is located at th

20 Color Channel Selector, allows you to select, invert, or gray the color channels of the image displayed. Note: This tool does not change

21  Equalized Color Channel Density – divides all color channel densities by a normalized color density. For example when “Equalize Red Den

22 FILM EVALUATION PANEL Film Evaluation Panel or “Analysis Window” displays evaluation data for any image or dose map in the Image Panel. T

23 The color channel spreader, spreads the color so that the selected image region is displayed with a color saturation between 0% and 100%.

24 region. To pan out, click and drag from bottom right to top left. Right click and hold to drag the histogram across the data range. Right

25 The Profile Panel shows the image profile along the user-defined path in the image. Click and drag in the image panel to create an image p

26 The Contour Panel displays the iso-line chart of the image for a given set of dose or color channel values (see image on the right). Right

27 The Surface Tab displays analysis data in a 3D surface. Options to change perspective, elevation, rotation are also available. T

1 INTRODUCTION (Video: http://www.youtube.com/watch?v=A26tTy2iF88) FilmQA™ Pro is a sophisticated, quantitative, analysis tool specificall

28 CALIBRATION (Video: http://www.youtube.com/watch?v=AKqpsFKprf0) The calibration process uses films irradiated with known doses to genera

29 There are two ways to introduce calibration data or images into FilmQA™ Pro. Film Calibration (Ordinary) is used when all the calibration

30 3. Specify the Regions of Interest (ROI) by enabling the “Selection Frame Tool”, from the Tool Bar located in the border to the left of t

31 4. The next step is to activate the calibration tool. At the end of the Film Calibration (ordinary) branch of the Case Tree click “Tool –

32  There are four calibration images in the folder. Open the first calibration image. A thumbnail appears in the previously empty data slo

33 (Note: There are shortcuts to copy and size ROI’s. Highlight an ROI, hold down the “Ctrl” key and then point and click to copy the ROI. By

34 Once all the images are imported, a calibration table and fitting function must be generated. In the bottom right corner of the Film Evalu

35  Options: Provides a menu of options to customize the calibration table The dose values can be entered manually from the keyboard or

36 Data will not be fitted and no plot will be displayed unless there is exactly one dose value for each row of response values. Note: A char

37  Color reciprocal linear vs. dose: X (D) =A + B / (D-C) where X (D) is the response at dose D and A, B and C are coefficients to be dete

2 INSTALLATION Recommended computer requirements for FilmQA™ Pro: Hardware: Processor: i7 RAM: 8 GB, 1333 MHz Graphics: U

38 For a higher dose ranges, e.g. 0-10 Gy the color rational linear function: X (D) = (A +BD) / (D+C) is often preferred. For even greater d

39 Alternatively, choose “Export” and select “Save as Fixed Calibration” (see red box above). In this case only the calibration will be saved

40  Add calibration as color mapping: Adds the calibration function as a tool to convert response values to dose. When this option is invok

41 DOSE MAP (Video: http://www.youtube.com/watch?v=pfcGM3yIHlU) To measure or evaluate a dosimetry film, it is necessary to first scan the

42 To demonstrate the dose map calculation, another case object will be added to the example from the previous section, Calibration. Specifi

43 Once the IMRT image has loaded, FilmQA™ Pro by default, uses triple-channel dosimetry and automatically builds a dose map and a consistenc

44  Dose map from single channel: Calculates dose for each channel independently  Dose map using density reference channel: Dual channel

45  User defined dose range: Scales the dose range of the dose map to the user’s values – this is helpful when the film image contains dar

46  Filtering: Contains filters that could be applied to any image data before calculating dose or uniformity maps.  Fiducial Detection:

47  Save all ‘Dose map (single scan)’ images as: Saves the dose film image  Save all images of the treatment case as: Saves the film imag

3 1. Download and run the installation file from www.filmqapro.com\install. 2. Navigate through the following prompts by hitting “Next>

48 The default when a dose map is calculated is “auto-scaling” and it works well unless the darkest areas in the image are not due to radiati

49 To change the axis units or to copy the image from the image panel, right-click on the axis of the image to change the the “Axes Type” fro

50 PLAN TO DOSE COMPARISON (Video: http://www.youtube.com/watch?v=8V0dZJ_mchY) In this Section the comparison of an IMRT treatment plan to

51 The “Data –dose map (read only)” slot could also be populated by copying and pasting image data from a spreadsheet. With the file to be c

52  Scan Image ‘Treatment plan’: Not operative  Paste CSV data as image to ‘Treatment plan’: Copy a plan from a spreadsheet to be posted

53 versions of the film itself (e.g. EBT3F or EBT3P) or scribed onto the patient film with pen by a user at the time the film was exposed. Th

54 The fiducial marks may have been highlighted when the dose map was calculated or the highlighting could be added at this stagewith the Fid

55 display in the Image Panel at this stage reveals the fiducial marks on the dose map are not aligned with the longitudinal and tranverse ax

56 horizontally, vertically and rotationally”,the dose map is automatically aligned with the in-plane and transverse axes and thereby with th

57 bottom of the Image Window when the Image movement tool is active. For translational movement click the arrows on the large square button

4 3. “Agree” to the licensing agreement to proceed 4. Click “Next>” to install the necessary files in the selected folder 5. Click “N

58 Click on the icon to choose the type of gamma map select between Gamma relative error, Gamma Normalized or Gamma Angle. Click on the

59 In the example Case the gamma test passing rate is >99.6% for 3% dose tolerance at 3 mm. Passing rates >99% for the 3%/3mm criteria

60 Note: For absolute dosimetry, do NOT adjust the maximum dose in the plan image. Maximum dose could be adjusted when doing relative dosimet

61 Right click anywhere in the chart to access another set of selections for the chart display and control the values along x and y axes, for

62 6. Full horizontal line: User sets the position of a horizontal line across the entire image 7. Circle: User defines a circular path 8.

63 slider controls translation along the x and y axes. There is an option to limit the profile path to the envelope of the Selection Frame (R

64  Use the to save or copy the Contour Level Palette or retrieve a saved Contour Level Palette. The Isomap Tab displays the isomap of

65 The Delta Map Tab shows the passing rates (gamma analysis in the example) for the all three color channels below the chart. The chart in

66 generates a projection map, i.e. the measured dose map is recalculated by averaging individual pixels values grouped to reproduce the spat

67 ONE SCAN PROTOCOL This efficient protocol was developed to simplify radiochromic film calibration and to avoid the complications of the p

5 7. When starting FilmQA™ Pro for the first time, the program will prompt you to generate a license (see the following message below): 8.

68 reference film, one reference film exposed to a known dose of radiation in addition to the exposed application film. Note: All films used

69 to film orientation, but it is also means that a calibration with three or four exposures can be done with less than one sheet of film. Al

70 Use the Calibration Statistics icon to display a table of calibration statistics in the Image Window. This table of consistency values d

71 Point the cursor and click on each fiducial mark to add highlight marks. The fiducial fitting senses the center of the highlight marks, no

72 Here’s where the One Scan Protocol can be applied. Display the image of the application and reference films in the Image Panel and draw a

73 Display the new dose map in the Image Window and look at the values in the Statistics table. The exposed reference film is now exactly 313

74 STAR SHOT ANALYSIS (Video: http://www.youtube.com/watch?v=CPtz-0dHbR8) I. SCOPE The protocol applies to GafChromic™ EBT2, EBT3 and EBT

75 strip for another use. The best way to tear EBT3+ is to grip the edge of the film as close as possible on either side of the perforation.

76 film with 150 MU at each position. Note: The ideal dose to the film for each beam is 100–200 cGy. Adjustment of MU should be made to achi

77 B. Collimator Star Shot 1. Tape a sheet of film at the center of one of the plastic slabs with the edges of the film and the slab roughl

6 11. After receiving the license key, save the key to the application folder in either “c:\Program Files\ISP Advanced Materials\FilmQA Pro 2

78 Figure 2: Collimator star shot C. Couch Star Shot 1. Tape a sheet of film at the center of one of the plastic slabs with the edges of

79 analysis in the following ways. As the slit becomes narrower more monitor units may be required to obtain the same darkening of the film.

80 Figure 3: FilmQA™ Pro – Opening screen 2. Select “MLC Star shot Physics QA” from the drop down menu Selecting “MLC Star shot Physics Q

81 3. Expand the MLC Starshot Physics Case Object and right click on “Data starshot #1 (empty)”. Click on “Scan Image starshot #1”. Alternat

82 Figure 4A Figure 4B Figure 4C 5. Put the star shot film in the center of the scanner and scan it. The analy

83 Figure 5: Gantry starshot film image and selection of vertical fiducial mark Figure 6: Gantry starshot with software fiducial marks in

84 Figure 7 . Figure 8

85 At this point the analysis is complete although small adjustments could be made by refining the default settings as described in the follo

86 intersection points has a radius of 1.3mm and the centroid formed by the intersection points is 0.8mm from isocenter. Adjust the diameter

87 The result (Figure 10) shows that 27 of 35 intersection points were used. The radius of the minimum circle encompassing all intersections

7 GETTING STARTED (Video: http://www.youtube.com/watch?v=5mAidqhL5qM) When FilmQA™ Pro loads, the following screen will appear: As you can

88 E. Analysis Circle Profile 1. Click on the “Profile” tab (see below) to display a profile along the paths of the two analysis circles as

89 pixel data. This tab will display the profile data along the analysis circles and the detected minima points (center of the beam lines). T

90 3. “Report Options”, , opens a pop-up window so the user can:  “Open/Save Document Template” – Loads or saves report settings  “Sho

91 noise is reduced by using relatively wider path widths with the provision not to include areas beyond the length of the exposed beam lines

92 5. Extrema cut-off limit: the tolerance for extrema inclusion. Choices are 0, 3, 5, 10, 15, 20, 30, 40, 50, 70 and 100%. 6. Profile star

93 FLATNESS AND SYMMETRY ANALYSIS Click on “Add New Case Object” under the “Case Object Management” heading. A drop-down menu will appear an

94 The flatness and symmetry tool automatically assigns the horizontal and vertical analysis path lines. Use the analysis configuration tool

95 The maximum or CAX value can be normalized between 0 and 1. If the base line of the profile is disturbed (left and right values are differ

96 PICKET FENCE ANALYSIS Click on “Add New Case Object” under the “Case Object Management” heading. A drop-down menu will appear and give yo

97 The picket fence analysis tools automatically detects the beam lines and displays the detected beam line points at the analysis path lines